Allopurinol and Endothelial Function in Heart Failure
نویسندگان
چکیده
منابع مشابه
Allopurinol and endothelial function in heart failure: future or fantasy?
Allopurinol and Endothelial Function in Heart Failure : Future or Fantasy? Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2002 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.0000024270.37833.F9 2002;106:173-175 Circulation. http://circ.ahajournals.org/conten...
متن کاملAllopurinol improves endothelial dysfunction in chronic heart failure.
BACKGROUND Increased oxidative stress in chronic heart failure is thought to contribute to endothelial dysfunction. Xanthine oxidase produces oxidative stress and therefore we examined whether allopurinol improved endothelial dysfunction in chronic heart failure. METHODS AND RESULTS We performed a randomized, placebo-controlled, double-blind crossover study on 11 patients with New York Heart ...
متن کاملAllopurinol and global left myocardial function in heart failure patients
BACKGROUND AND AIM Increased xanthine oxidase (XO) activity may contribute to heart failure pathophysiology. This study evaluated whether a XO inhibitor, allopurinol produces clinical and functional benefits in patients with New York Heart Association functional class III to IV heart failure due to systolic dysfunction receiving optimal medical therapy as estimated by global left myocardial fun...
متن کاملGout, allopurinol use, and heart failure outcomes.
BACKGROUND Hyperuricemia is associated with reduced survival among patients with heart failure (HF), but the effect of gout on HF outcomes is unknown. A recent randomized trial suggested that allopurinol may reduce adverse outcomes among patients with hyperuricemia and HF. Our objective was to determine whether gout and allopurinol use are associated with HF outcomes. METHODS Time-matched, ne...
متن کاملHeart failure, oxidative stress and allopurinol.
Oxidative stress is one of the new and most intriguing pathogenetic hypotheses of heart failure; it involves various mechanisms such as endothelial dysfunction, mechano-energetic uncoupling and apoptosis. Xanthine oxidase, a key enzyme in purine catabolism, is overexpressed in patients with heart failure, and it is also an important source of oxidizing activity molecules (free radicals, superox...
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ژورنال
عنوان ژورنال: Circulation
سال: 2002
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000024270.37833.f9